On Tuesday, he played his final home game in front of the Miami fans, scoring 30-points in a win and flashing glimpses of vintage Wade. Nor will it be up for auction-at least not anytime soon.
D'Angelo Russell, who ended his rookie season by appearing in Kobe Bryant's last game in 2016 with the Los Angeles Lakers, led the Nets with 21 points.
After a 16-year NBA career, Wade leaves the game with 3 NBA championships, an NBA Finals MVP, 13 All-Star appearances and eight All-NBA teams.
Should it ever come to auction, it's likely the jersey would sell for at least a high five-figure price tag, perhaps significantly more.
With the help of Opta, we take a look at how James, Anthony, Bosh and Wade have fared since they entered the league.
The images of Wade celebrating with LeBron, Anthony and Paul are a reminder of what an incredible era of basketball we've just been treated too, and that it's coming to a close.
"Obviously, it means a lot [to have them here]", Wade said.
In his final regular season game against the Brooklyn Nets at the Barclays Center, Wade's friends - known as the "Banana Boat" crew - sat courtside and witnessed his 25-point, 11-rebound and 10-assist performance, notching the fifth and final triple-double of his career.
"I didn't get an opportunity to play against Melo this year and exchange jerseys with him", Wade said. That was the missing piece out of this whole season. "I thank you guys for dancing with me this year". "That's the same way I went out in college". That's been the cool thing about this.
"I've been there. In my case though, I didn't really have a choice".