In Game 1 of Miami's first-round series against the New Orleans Hornets, Wade sank the game-winning floater with one second to play to lift the Heat to an 81-79 thrilling win.
However, before he can ride off into the sunset, Wade had one more game on the schedule as Miami visited Brooklyn to take on the Nets.
James went to the NBA Finals with the Heat as a Wade teammate from 2011 to 2014, with championships in 2012 and '13.
TOP PERFORMERS: D'Angelo Russell leads the Nets averaging 2.8 made 3-pointers and scoring 21.1 points per game while shooting 36.4 percent from beyond the arc. The Nets also clinched their first winning season since 2013-14 by going 34-22 over their last 56 games since December 7.
Wade played 36 minutes and received a loud hand from fans each time he touched the ball. Miami was eliminated from contention for it despite its victory Tuesday.
"Dwyane Wade: Heart of the Heat" covers it all in depth - and with heart. "Unfortunately for our organization and our team, we weren't able to put ourselves in a position to win enough games to be in the playoffs, but for what I wanted for this season, I'm happy to say that I completed that". DeMarre Carroll will sit out due to a sprained right wrist while Harris - who leads the National Basketball Association in 3-point shooting percentage - is questionable because of a sore right foot.
"I didn't get an opportunity to play against Melo this year and exchange jerseys with him", Wade said. In return she gave him her cap and gown.