A reputed NY crime boss was shot and killed outside a home Wednesday night.
The New York Police Department says that at 9:17 p.m. ET, officers received a 911 call reporting an assault in progress in front of Cali's house at 25 Hilltop Terrace.
Cali was rushed to Staten Island University North Hospital, where he was pronounced dead.
No arrests have been made and an investigation is ongoing as police search for a blue pickup truck that fled the gruesome scene after it is believed to have run Cali over.
It's more than three decades since the last hit on a boss of one of the five families, but Cali's murder is a reminder that - at least as far as the rest of us know - the Mafia really did split up NY into five territories, and continues to operate that way despite huge numbers of arrests over the years.
The Gambino family is one of five mafia families that have always been seen as running Italian-American organized crime syndicates in NY.
The Gambino family is one of New York's five historic Italian Mafia families - along with the Genovese, Lucchese, Colombo and Bonanno families.
One of the most notorious gangs of NY is at the center of a new mob murder mystery.
Cali, who served on the family's ruling panel for several years, was elevated to acting boss in 2015, replacing then 68-year-old Domenico Cefalu.
Following Castellano's murder, which saw the boss dramatically gunned down outside a Manhattan steakhouse after stepping out of a black limo, Gotti took over as the Gambino family don.
Cali became the de facto godfather of the Gambinos in 2015. He was sentenced to 16 months in federal prison and was released in 2009.
The reputed boss of New York's Gambino crime family was shot to death in front of his home by a gunman who may have staged a auto accident to lure him outside, dying a virtual unknown compared with his swaggering 1980s-era predecessor, John Gotti.
"He has a conversation with an individual in front of that residence and that individual at some point in time, it's only about a minute into it, pulls out a firearm and shots are fired", said NYPD Chief of Detectives Dermot Shea.