The 34-year-old also added 14 rebounds and nine assists in the win, finishing an assist shy of a triple-double, and he believes the Lakers can put themselves back in the postseason conversation once he gets back to full fitness.
"I haven't felt like this in a long time", he said.
James, who missed 17 games due to a groin injury, scored a team-high 24 points, grabbed 14 rebounds and delivered nine assists in his first National Basketball Association game since Christmas Day.
In a game where the Lakers led by as many as 14 points, the Clippers outscored them 37-25 in the fourth quarter to force an overtime (112-112).
Watch LeBron James' individual highlights from his victorious comeback on Thursday night in the video at the top of this page.
James' return couldn't come soon enough for the Lakers, who have gone into a tailspin without him.
"I'll gain my rhythm as the season continues, and I'm looking forward to seeing how I feel tomorrow".
After upping his rehab this week, the four-time NBA MVP finally made his comeback against the Clippers, James scored 24 points in a 123-120 victory. "I told our coaches then, he's in". Everybody was huge. It is going to be different guys every night for our team.
James has not played in nearly five weeks as he injured his groin against the Golden State Warriors on Christmas Day.
Lou Williams scored a team-high 24 points and Patrick Beverley added 17 for the Clippers, who shot just 53 percent from the free-throw line.
"You can't control your destiny in this league, but you can control your work ethic and how great you want to be".