Sayoc was taken into custody on Friday morning outside a vehicle parts store in Plantation, Florida, federal authorities said.
Sayoc, a 56-year-old registered Republican, lives in Aventura, Florida, near the facility from where numerous packages were mailed, authorities said.
Earlier on Friday, authorities said suspicious packages addressed to New Jersey Sen. Kamala Harris; and another in NY addressed to James R. Clapper Jr., the Obama-era director of national intelligence.
Prior to the arrest, Attorney General Jeff Sessions said on Friday that the Justice Department was dedicating every available resource to the investigation and "I can tell you this: We will find the person or persons responsible".
A person has been arrested in connection with a mail-bombing campaign aimed at Trump critics, U.S. officials say.
According to the Times, Sayoc is a registered Republican with a criminal history that includes theft, drug and fraud charges, as well as an arrest for an alleged threat to use a bomb.
He filed for bankruptcy in Miami in 2012, according to court records.
The man, who still remains unnamed, was arrested at a business in Plantation, Florida, a suburb of Miami.
In the 2002 bomb threat case, Sayoc pleaded guilty to the felony without a trial and was sentenced to probation, the records show. One was intercepted in New York City at a postal facility.
"I ain't scared", said Waters in an interview with Blavity, a media outlet aimed at Black millennials. The Twitter account also ranted about Debbie Wasserman Schultz, whose return address was used to send the mail bombs, and included threats against other liberal public figures including New York Times columnist and tech writer Sarah Jeong and actor Jim Carrey, The Daily Beast reports.
Sayoc allegedly sent 13 suspicious packages to people including former President Barack Obama, former Secretary of State Hillary Clinton and former Vice President Joe Biden. Maxine Waters was key to cracking the case, FBI Director Christopher Wray said. Sayoc said "it would be worse than September 11" and also threatened something would happen to the FPL representative he was talking to if the utility cut his electricity. The most recent packages were intercepted on Friday in California, Florida and NY targeting Harris, Booker and former intelligence chief James Clapper, another prominent Trump critic.
The Department of Homeland Security has said there are no links to worldwide terrorism.
The Context: As of Friday morning, there have been a total of 11 bomb targets and 14 bombs.
According to Wray, as well as NYPD Commissioner James O'Neill, there may be other risky packages still in transit or in postal warehouses, so it's important that Americans be aware, alert, and ready to report anything suspicious.
The first of the bombs surfaced on Monday at the Westchester County, New York, home of billionaire Democratic donor George Soros.
New York Police Commissioner James O'Neill could not confirm whether all the devices were meant to explode, but he said officials "are treating them as suspected explosive devices".