Liverpool have only conceded one goal this season, to Spurs' four, but share their richest talent further up the pitch.
"We don't play Champions League or what?" said the German, whose side now top the table with a 100 per cent record after four matches and are widely seen as the main challengers to defending champions Manchester City.
"How do you prepare for a game and not focus on it?"
Liverpool beat Manchester City in the quarter-finals of last season's Champions League before eventually losing to Real Madrid in the final.
The 22-year-old midfielder could also be ruled out of next Tuesday evening's (Wednesday morning AEST) UEFA Champions League opener away to Inter Milan.
"I know the situation is not like people expected".
"We are disappointed because we're going to miss him for this game and possibly Inter Milan in the Champions League, but it is not a big issue". "He is the first to tell me that he made a mistake, this is a lesson for everyone". We have to play football. It will be interesting to see who Klopp picks in midfield, but there is a strong chance that Naby Keita will be back in the XI after he missed out last time, probably alongside James Milner and one other. "I'm not even going to put Arsenal there", he added.
Just four months ago, Tottenham striker Kane and Liverpool forward Salah were being hailed as Europe's most feared marksmen after the pair tore through Premier League defences on a weekly basis.
Unlike Spurs' England contingent, Klopp has bedded captain Jordan Henderson slowly back into action, while Mohamed Salah and Sadio Mane's early exits in Russian Federation with Egypt and Senegal meant they had a few weeks of pre-season training. "We have to play football".
"I think Liverpool haven't started the season excellently, but they have done a good job, and out of all the teams out there they've looked the best, and in [Virgil] van Dijk they've got one of the best defenders in the world at the moment".